SMLE clinical practice questions
Practise clinical decision questions with explanations and source references. Question wording, references and teaching points continue to improve as items are reviewed.
2026 Blueprint Domain Inventory
30% WeightTopic-based practice
Internal Medicine
Cardiology, Pulmonology, Endocrinology, Nephrology, Infectious Diseases
25% WeightTopic-based practice
Pediatrics
Neonatology, Pediatric Emergency, Development, Vaccination, Nutrition
25% WeightTopic-based practice
Obstetrics & Gynecology
Antenatal Care, Labor Complications, Gyn Oncology, Contraception
20% WeightTopic-based practice
General Surgery
Acute Abdomen, Trauma Resuscitation, Breast Disease, Perioperative Care
Sample High-Yield Clinical Scenarios & Rationale Architecture
Select an option below to reveal our structured 5-part explanation model:
Internal MedicineSample Item 1 of 5
A 32-year-old man presents to an outpatient clinic with a 4-week history of undulant low-grade fever, night sweats, fatigue, and severe lower back pain. He reports frequently consuming unpasteurized raw camel milk from a livestock farm. On physical examination, there is point tenderness over the L4-L5 lumbar vertebrae and sacroiliac joint. Serum agglutination test (SAT) is positive at a titer of 1:320. Which of the following is the most appropriate antimicrobial regimen?